Substance P is a neuropeptide derived from preprotachinin. Substance P is widely distributed in the central and peripheral nervous system. In sensory ganglia, it is expressed by small sensory neurons and is transported to their central and peripheral terminals. The role of substance P in sensory transmission has been studied extensively, and its involvement in nociception and chronic pain is well established. Our guinea pig anti-substance P antibody provides an excellent tool for multicolor immunofluorescence experiments.
Image: Detection of Substance P in mouse spinal cord (red fluorescence). Tissue was counterstained with Fluoro Nissl Green (green fluorescence).
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