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Orexin A and orexin B are neuropeptide hormones derived from proteolytic processing of the same orexin precursor protein. Orexins are named for their orexigenic-inducing (orexis; Greek for appetite) activity. They are released from the hypothalamus and are involved in the regulation of sleeping patterns, feeding, and metabolism. Orexins A and B are less than 50% amino acid identical. Orexin A is a ligand for two 7-transmembrane orexin receptors, OX1R and OX2R, while orexin B preferentially binds OX2R. Defects in the orexin precursor are a cause of narcolepsy in humans.
Image: Orexin B and p38 alpha were detected in frozen sections of mouse brainstem using mouse anti-human Orexin B monoclonal antibody (red) and rabbit anti-human/mouse/rat p38 alpha affinity-purified polyclonal antibody (green).
This antibody was selected specifically for its ability to recognize human Orexin B in immunohistochemistry applications. It does not cross-react with human Orexin A.