Network with Neuromics
Contact Information
Neuromics
5325 West 74th St., Suite 8
Edina, MN 55439
Toll free: 866-350-1500
Int'l phone: 952-374-6161
Fax: 612-677-3976
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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| MO15081 | 100 ug | $235.00 | Buy Now | Add to Cart |
Type: Mouse IgG
Applications: WB; FC
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;
Species Reactivity: H; M; Pr; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Protein G Purified - liquid
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf21-derived, recombinant human insulysin/insulin degrading enzyme (rhIDE; Accession # NP_004960, aa 42 – 1019). Clone#: 334501.
Description/Data:
Insulysin, a wide expressed protein, is responsible for the degradation of insulin in cells. Primarily located in the cytosol, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B-chain, glucagon, denatured hemoglobin, alpha-amyloid protein, TGF-alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer's disease research.
Figure: HeLa cells were stained with anti-Insulysin (filled histogram) or isotype control (open histogram) followed by APC-conjugated rat antibody.