Plexin A3

Affinity Purified Goat Antibody
DATASHEET(pdf - 163Kb)
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Type: Goat IgG
 
Applications: IHC; WB; E
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5;
Species Reactivity: H; M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Affinity Purified - liquid
 
Immunogen: Produced in goats immunized with purified, E. coli-derived, recombinant mouse Plexin A3 (rmPlexin A3; aa 34 - 150; Accession # P70208).
 
Description/Data:
Picture

Plexin A3 (also known as SEX) is a 220 kDa member of the Plexin A subfamily of semaphorin receptors. Mature mouse Plexin A3 is predicted to be an 1853 amino acid (aa) type I transmembrane glycoprotein that contains a 1202 aa extracellular domain (ECD) and a 629 aa cytoplasmic region. The ECD contains one semaphorin domain (aa # 34 - 473), three plexin-semaphorin-integrin (PSI) domains (aa # 492 - 830), and four lg-like plexin-transcription factor (IPT) repeats (aa # 841 - 1209). Plexin A3 interacts with neuropilins 1 and 2, and binds class 3 semaphorins. Over aa # 35 - 150, mouse Plexin A3 is 99% and 97% aa identical to rat and human Plexin A3, respectively.

Plexin A3 is involved in the development of neural and epithelial tissues.

Image: Detection of Plexin A3 in mouse embryonic (E13.5) spinal cord. Cells were stained using NorthernLightsTM 577 fluorochrome labeled secondary antibody (red) and counterstained with DAPI (blue).

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