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CH23002100 ul$99.00Buy Now | Add to Cart
Type: Chicken IgY
Applications: ICC; IHC; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
Immunogen: Peptide common to mouse (O09118) and human (O95631) Netrin-1

Murine netrin-1 precursor is a 67,768 dalton protein (604 amino acids) expressed by subpopulations of cells within the developing CNS, as well as in various non-neural tissues, including the gut, liver, heart, and prostate. In the embryonic CNS, netrin-1 is expressed by cells of the floor plate, and acts to attract axons of commissural neurons from the dorsal horn gray matter. Netrin-1 is also believed to play a role in the growth of motor axons in the PNS.

Image: Dissociated cell cultures of an e13 mouse brain showing Netrin-1 (green staining) in neuronal precursor cells.

Netrin-1: Customer Publications 












Images: Immunohistochemical colocalization of netrin-1 and endothelial markers. Paraformaldehyde-fixed frozen tissue sections were stained with anti-netrin-1 antibody (red stain) and anti-Von Willebrand Factor (VWF) antibody (green stain) as described in MATERIALS AND METHODS. Nuclei were stained blue with DAPI. In sham-operated kidney (BD), netrin-1 staining was mainly in the interstitium and colocalized with VWF. Similarly, netrin-1 and VWF colocalized in the kidney section from 72 h of reperfusion (E and F). No staining was seen in the primary antibody negative control (A). Colocalization of netrin-1 (red) and GFP (green) in kidney from Tie2-GFP mice was also observed under normal conditions (G and H). doi:10.1152/ajprenal.00508.2007.


Image: Immunohistochemical localization of netrin-1 in renal cell carcinoma (RCC) tissues. A. Secondary antibody control showing no staining. B. Normal adjacent tissues do not show any staining for netrin-1. C. Stage I RCC shows staining for netrin-1. D. Stage II RCC shows staining for netrin-1. E&F. doi: 10.3109/1354750X.2010.541564