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Human TH (EC 220.127.116.11) is a 58,523 dalton protein (528 amino acids) responsible for the enzymatic conversion of l-tyrosine to l-DOPA (dihydroxyphenylalanine). This enzyme is expressed in all catecholaminergic neurons of the CNS and PNS. In the CNS, TH-positive neurons can be found within the substantia nigra, ventral tegmental area, locus ceruleus, and hypothalamus. In the PNS, TH-positive neurons can be found within the sympathetic chain, pre-vertebral ganglia and the adrenal medulla.
Image: Tissue section through an adult mouse brain showing TH (red staining) in catecholaminergic neurons of the substantia nigra (pars compacta). The green staining is the autofluorescence of green fluorescent protein (GFP) in neurons in this transgenic animal.
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Image: TH (tyrosine hydroxylase, an excitatory neuronal marker) staining of STEMEZ(TM) hNP1 Human Neural Progenitors. doi:10.1089/ten.tea.2009.0155.