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Type: Guinea Pig IgG
Applications: IHC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Whole serum - liquid

Human CD39 is found on most mature B cells, activated NK cells and activated T cells. CD39 is also weakly expressed on granulocytes. CD39 has homology to the Nmyc family of proteins and was recently cloned. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis

CD39 could ould also play a in type 2 Diabetes.

Image: CD39 distribution in rat pancreatic ducts. J Physiol (2003), 551.3, pp. 881-892 © Copyright 2003 The Physiological Society. DOI: 10.1113/jphysiol.2003.049411

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Images: Detection of immunoreactive CD39 and CD73 in the effluent of ischemia reperfusion. The effluent samples (300 μl) from pre-ischemia (3) and ischemia-reperfusion hearts (4) were applied to nitrocellulose membrane, and subjected to dot blot analysis with anti-CD39 antibody (A) and anti-CD73 antibody (B). As the negative and positive control, membrane extract (30 μg protein in 300 μl) from HEK293 cells transfected with control pcDNA3vector (1 in A and B) or CD39- (2 in A) and CD73-expressing plasmid (2 in B) were used. Results shown are representative of three separate sets of experiments. Takahashi-Sato et al. BMC Cardiovascular Disorders 2013 13:53 doi:10.1186/1471-2261-13-5