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Type: Mouse IgG
Applications: FC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Protein G Purified - liquid
Immunogen: Clone #: 42704

The human C-X-C chemokine IL-8 is a potent neutrophil chemotactic and activating factor (1). Two distinct cell surface receptors can interact with the IL-8 molecule. These two structures are known as IL-8RA (type I or CXCR-1) and IL-8RB (type II or CXCR-2) (2, 3). The two receptors share 77% amino acid homology and are both members of the rhodopsin superfamily of G protein-linked receptors that span the cell membrane with seven hydrophobic transmembrane domains. Of the two IL-8 receptors, only IL-8RA exclusively binds IL-8 (4). A third IL-8 binding structure, known as the Duffy blood group antigen, has been identified on red blood cells (5). IL-8RA expression has been documented on neutrophils, monocytes and a small population of T cells (2).


1. Oppenheim, J.J. (1991) Annu. Rev. Immunol. 9:617.

2. Holmes, W.E. et al. (1991) Science 253:1278.

3. Murphy, P.M. and H.L. Tiffany (1991)

Science 253:1280.

4. LaRosa, G.J. et al. (1992) J. Biol. Chem. 267:25402.

5. Horuk, R. et al. (1993) Biochemisry 32:5733