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GT15192100 ug$365.00Buy Now | Add to Cart
 
Type: Goat IgG
 
Applications: IHC; WB; E
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: Purified, E. coli-derived, recombinant human Mothers against DPP homolog 5 (rhSmad5; aa 155 - 258).
 
Description/Data:
Picture

SMAD5 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight SMADs have been identified and can be divided into 3 subgroups based on their structure and function; pathway-restricted, common mediator and inhibitory. SMAD1, 5 and 8 serve as pathway-restricted SMADs for the bone morphogenetic protein (BMP) signaling pathway. SMAD5 is directly activated by BMP type Ia or Ib receptors upon BMP-2 stimulation and transduced BMP-2 signals to the nucleus by forming a complex with SMAD4.

Smad5 could be a marker for several forms of cancer inluding colo-rectal.

Image: SMAD5 staining paraffin-embedded human colon tissue sections (dilution  5 µg/mL). Tissues were stained usiing anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).