|Catalog Number||Size||Price (USD)||Shopping Cart|
|GT15192||100 ug||$365.00||Buy Now | Add to Cart|
SMAD5 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight SMADs have been identified and can be divided into 3 subgroups based on their structure and function; pathway-restricted, common mediator and inhibitory. SMAD1, 5 and 8 serve as pathway-restricted SMADs for the bone morphogenetic protein (BMP) signaling pathway. SMAD5 is directly activated by BMP type Ia or Ib receptors upon BMP-2 stimulation and transduced BMP-2 signals to the nucleus by forming a complex with SMAD4.
Smad5 could be a marker for several forms of cancer inluding colo-rectal.
Image: SMAD5 staining paraffin-embedded human colon tissue sections (dilution 5 µg/mL). Tissues were stained usiing anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).
Neuron-Glial Expressed-Includes Neurotrophin Proteins
Apoptosis Research Reagents-Apoptosis Categories-includes: detection kits, antibodies and proteins