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MO20024100 ul$155.00Buy Now | Add to Cart
 
Type: Mouse IgG
 
Applications: IHC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Ascites Fluid - liquid
 
Immunogen: Prokaryotic recombinant protein corresponding to the entire human calretinin molecule. Clone: CAL6
 
Description/Data:
Picture

Calretinin  (CAL6). a member of the family of so-called EF-hand proteins that also includes S-100 proteins, is a 29 kDa calcium binding protein that is expressed in central and peripheral nervous system and in many normal and pathological tissues.

Outside the nervous system, calretinin is reported to be expressed in a range of cell types including mesothelial cells, steroid producing cell, (eg adrenal cortical cells, Leydig cells, ovarian theca interna cells as well as Sertoli cells, some neuroendocrine cells, eccrine sweat glands) and other cell types.

Image: Calretinin staining of human mesotheliom. Note cytoplasmic staining of malignant cells. Paraffin section.

The presence of calretinin is reported to be a useful marker primarily for differentiating malignant mesothelioma from carcinomas. Other reports indicate the detection of calretinin is helpful for the differential characterization of ovarian stroma tumors. Calretinin-positive cells have also been reported in the convoluted tubules of kidney with some antibodies.