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RA3002650 ug$365.00Buy Now | Add to Cart
 
Type: Rabbit IgG
 
Applications: E; IHC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: KLH Coupled Synthetic Peptide- Amino acids 320 to 335 of human WISP3.
 
Description/Data:
Picture

WISP3 is a member of the CCN (for CTGF, CYR61), and NOV gene family, which encode cysteine-rich secreted proteins with roles in cell growth and differentiation. WISP3 is likely required for normal postnatal skeletal growth and cartilage homeostasis. WISP3 is predominantly expressed in adult and fetal kidney and adult testis

Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging.

Image: WISP-3 staining of Human Small Intestine. Formalin-Fixed Paraffin-Embedded (FFPE).