|Catalog Number||Size||Price (USD)||Shopping Cart|
|RA30031||50 ug||$365.00||Buy Now | Add to Cart|
The Frizzled 7 (FZD7) protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Frizzled family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. Frizzled 7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. Frizzled 7 expression has been reported in brain, gastrointestinal tract, heart, fetal kidney, fetal lung, placenta, skeletal muscle, and various cancers. ESTs have been isolated from a wide variety of normal and cancer libraries.
Image: FZD7 staining of Human Heart Tissue. Formalin-Fixed Paraffin-Embedded (FFPE).