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Type: Mouse IgG
Applications: ICC; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Supernatant - liquid
Immunogen: Recombinant mouse Tyrosine Hyrodxylase protein Carboxy-terminus

Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.

Right Hand Image: TH staining of human mid-brain. Note cytoplasmic staining of catecholaminergic cells and their processes. Paraffin section (Peroxidase substrate: nickel DAB, Counterstain: eosin).

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Images:  Immunoperoxidase (A and C) and immunofluorescent (B, D–H) labeling of intrinsic cardiac adrenergic (ICA) cells in human hearts are shown. ICA cells expressing tyrosine hydroxylase (TH) immunoreactivity (red) are distributed diffusely throughout the left ventricular (LV) myocardium. Perivascular location is a frequent feature of ICA cells. C, arrow: terminal arteriole. E: abundant ICA cells in the smooth muscle layers of epicardial circumflex coronary artery. TH-expressing sympathetic nerve fibers (D and G, arrows) can occasionally be seen in the field. B and D, insets: magnified ICA cell images (arrows). TH immunoreactivity (green) was identified in ICA cells and sympathetic nerve fibers in the sinoatrial nodal tissue (G). ICA cells are seen in transplanted human LV tissue (H). Scale bars = 10 µm, except in B (20 µm).  Am J Physiol Heart Circ Physiol 293: H376-H384, 2007