CXCR4

Chemokine receptors are seven-transmembrane domain G-protein coupled receptors that mediate the biological activities of chemokines. Most of these receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. They are named according to the chemokine subfamily they bind. There are currently six CXC-specific receptors designated CXCR1 to CXCR6, eleven CC-specific receptors designated CCR1 to CCR11, and one C receptor, XCR1. CX3CR1 is the receptor for fractalkine.

Image: CXCR4 staining on human lymph node. Cells were stained using ABC-HRP + AEC (red) and Haematoxylin (blue).

Image: CXCR4 staining of  human peripheral blood mononuclear cells using  rhodamine red Xconjugated antimouse secondary antibody. Cells are counterstained with Fluoro Nissl (green).