|Catalog Number||Size||Price (USD)||Shopping Cart|
|GT15099||100 ug||$365.00||Buy Now | Add to Cart|
GATA proteins are transcriptional coactivators with two GATA-type zinc fingers. GATAs bind to the consensus DNA sequence (A/T) GATA (A/G) to control diverse tissue-specific programs of gene expression and morphogenesis. GATA-1, -2, -3 are selectively expressed in hematopoietic and endothelial cells, while GATA-4, -5, and -6 are expressed in developing heart and gut-derived tissues. GATA-1 and -3 exist in multiple alternatively spliced isoforms.
Image: Detection of Human GATA2 by Western Blot. Western blot shows lysates of NIH 3T3 mouse embryonic fibroblast cell line and KG1 human acute myelogenous leukemia cell line. PVDF membrane was probed with 0.5 μg/mL of Human GATA2 Antigen Affinitypurified Polyclonal Antibody followed by HRPconjugated AntiGoat IgG Secondary Antibody .A specific band was detected for GATA2 at approximately 51 kDa (as indicated).
GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation.