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The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate.
SOX17 is a member of the SOX family of transcription factors that bind DNA via a high mobility group (HMG) domain. SOX17 is suggested to play an important role in endoderm development.
Image: SOX17 staining of endodermal cells derived from human embyronic stem cells. Cells were stained using Rhodamine Red-conjugated donkey anti-goat secondary antibody and counterstained using Fluoro Nissl (green). Courtesy of Dr. Jong-Hoon Kim and Dr. Ron McKay from the National Institute of Neurological Disorders and Stroke & Stem Cell Unit at NIH.
For flow cytometry using SOX 17 see: SBDR - SOCIETY FOR BIOMEDICAL DIABETES RESEARCH
Turning Human Epidermis Into Pancreatic Endoderm.
Sox17: Customer Publications
Image: SOX17 protein is present in various maturation stages of spermatogenesis: spermatogonium (black arrow), secondary spermatocyte (white arrow), and spermatid (black arrowhead), while primary spermatocytes, spermatozoa, and Sertoli cells are negative. 10.1002/path.2332. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.