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Type: Mouse IgG
Applications: IHC; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Protein G Purified - liquid
Immunogen: Recombinant human SOX2

The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate.

SOX2 belongs to the SOX (SRY-like HMG box) family of transcription factors with diverse roles in development. SOX2 functions in specifying the first three lineages present at implantation and inregulating proliferation and differentiation in the developing peripheral nervous system.1 - 5

Image: SOX2 staining of human NTERA-2 cells. Cells were stained using Rhodamine Red-conjugated donkey anti-Mouse IgG secondary antibody.

SOX2 Customer Publications

Customer Testimonial: "Thanks for your interest in our work and for including our paper in your blog posting: (SOX2 and Initiation of Breast Tumors). The antibody from Neuromics was the best of all we tested, we'll keep using it." Dr. Angel García Martín, PhD, Group Leader InBiomed.

General References:
1. Graham, V. et al., 2003, Neuron 39(5):749 - 765.
2. Avilion, A.A. et al., 2003, Genes Dev. 17(1):126 - 140.
3. Kishi, M. et al., 2000, Development 127(4):791 - 800.
4. Yuan, H. et al., 1995, Genes Dev. 9(21):2635 - 2645.
5. Uwanogho, D. et al., 1995, Mech. Dev. 49(1-2):23 - 36.
6. Stevanovic, M., 2003, Mol. Biol. Rep. 30(2):127 - 132.