|Catalog Number||Size||Price (USD)||Shopping Cart|
|MO15049||100 ug||$255.00||Buy Now | Add to Cart|
Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson's. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer's disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders.
Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.
Image: Musashi-1 immunoreactivity in human brain tissue using mouse anti-human Musashi-1 monoclonal antibody (Red); counterstained with Fluoro Nissl (green).