Potassium K+ Channels
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential, and in neuronal excitability and plasticity. In addition, they regulate heart rate, insulin secretion, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic TM domains with a P-domain between the fifth and sixth, which partially resides in the membrane. The fourth TM domain has positively charged residues at every third residue and acts as a voltage sensor, which triggers the conformational change that opens the channel pore in response to a displacement in membrane potential.
Image: Kv1.1, 1.2 and 1.3 protein is expressed in cultured dopamine neurons. X60 confocal images of mature dopamine cultures showing immunocytochemical colocalization of DAT (green) and Kv1.1, 1.2 and 1.3.13, 2011, doi: 10.1074/jbc.M110.153262.
Inwardly-rectifying potassium channels (Kir) are the principal class of two-TM domain potassium channels. They are characterised by the property of inward-rectification, which is described as the ability to allow large inward currents and smaller outward currents. KChIPs are Kv channel-interacting proteins that bind to the cytoplasmic amino termini of Kv4a-subunits and are integral components of native Kv4 channel complexes.
Changes in K+ channel function have been associated with cardiac hypertrophy and failure, apoptosis and oncogenesis, and various neurodegenerative and neuromuscular disorders.
|ATPase Na+/K+ transporting alpha 1||MO25023||Mouse IgG||Ca; H; M; Pr; R; Rb||FC; ICC; IF; IHC; WB||50 ul||$335|
|Kir2.1 K+ channel||MO50013||Mouse IgG||M; R||ICC; WB||100 ul||$275|
|Kir2.2 K+ channel||MO50014-100||R||ICC; WB||100 ul||$325|
|Kv1.1 K+ channel||MO50015||Mouse IgG||H; M; R||ICC; IHC; WB; IP||100 ul||$275|
|Kv1.2 K+ channel||MO50016||Mouse IgG||H; M; R; Xe; Ze||ICC; IHC; WB; IP||100 ul||$275|
|Kv1.3 K+ channel||MO50017||Mouse IgG||H; M; R||ICC; IHC; WB; IP||100 ul||$275|
|Kv1.4 K+ channel||MO50018||Mouse IgG||H; M; R||ICC; IHC; WB; IP||100 ul||$275|
|Kv2.1 K+ channel||MO50019||Mouse IgG||H; M; R||ICC; IHC; WB; IP||100 ul||$275|
|Kv3.1b K+ channel||MO50020-100||H; M; R||ICC; WB||100 ul||$325|
|Kv3.1 K+ channel (pSer503)||RA25020||Rabbit IgG||R||IF; IHC; WB||100 ul||$295|
|Kv4.2 K+ channel||MO50021||Mouse IgG||M; R||IF; IHC; WB; IP||100 ul||$275|
|Kv7.1/KCNQ1 K+ channel||MO50022||Mouse IgG||H; M; R||IF; IHC; WB||100 ul||$275|
|Kv7.2/KCNQ2 K+ channel||MO50023||Mouse IgG||H; M; R||IF; IHC; WB||100 ul||$275|
|KChIP1 K+ channel||MO50011||Mouse IgG||H; M; R; Xe; Ze||ICC; IHC; IP||100 ul||$275|
|KChIP2b K+ channel||MO50012||Mouse IgG||H; M; R; Xe; Ze||IHC; WB; IP||100 ul||$275|
|TREK 1||RA25018||Rabbit IgG||H||WB||100 ul||$245|