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Transforming growth factor (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.

  • TGFα is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development.
  • TGFβ exists in three known subtypes in humans, TGFβ1, TGFβ2, and TGFβ3. These are upregulated in some human cancers, and play crucial roles in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system. Isoforms of transforming growth factor-beta (TGF-β1) are also thought to be involved in the pathogenesis of pre-eclampsia. TGFβ receptors are single pass serine/threonine kinase receptors.

Image: Paraffin-embedded tissue sections of human brain stained with anti-TGF-beta3. HRP-DAB (brown)shown TGF-beta3 immunoreactivity and Haematoxylin (blue) counterstain.

NameCatalog #TypeSpeciesApplicationsSizePrice
Activin RIIAGT15149Goat IgGHIHC; WB; E100 ug$365
TGF betaMO20012Mouse IgMHIHC100 ul.$150
TGF beta 1MO15106Mouse IgGH; M; Pr; RIHC; WB; FC; E500 ug$325
TGF beta RI (type1)MO20011Mouse IgMHIHC100 ul.$250
TGF beta RII (type2)GT15073Goat IgGHIHC; WB; E100 ug$345
TGF-beta3GT15074Goat IgGHIHC; WB; E; NB100 ug$365