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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| MO25010 | 100 ul | $475.00 | Buy Now | Add to Cart |
PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.
It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors
Customer Testimonial and Image: The PGP mouse that we received from Neuromics works fantastically! I used it at 1:100 with Cy3 at 1:500 and got great staining with good background levels. PGP9.5 staining of Rat Abdominal Tissue. Courtesy of Jamie Nugent (Dr. Marna Ericson's Lab), University of Minnesota..
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Schwann Cell or PNS Neuronal Markers Neurodegenerative Disease Research Antibodies
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Neuron-Glial Expressed Proteins Primary Neurons and Astrocytes-Primary human, rat and mouse neurons and astrocytes by Category |