PGP9.5

Whole Serum-Rabbit Antibody
DATASHEET(pdf - 112Kb)
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Type: Rabbit IgG
 
Applications: IHC; WB
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;
Species Reactivity: H; M; P; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins
Format: Whole serum - liquid
 
Immunogen: ASSEDTLLKDAAKVCR
 
Description/Data:
Picture

PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.

It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for  cells of the diffuse neuroendocrine system and their tumors

PGP9.5 176-191 Customer Publications

More Links:

PGP 9.5/UCHL1 Antibodies

PGP9.5 Recombinant Protein

Pain and Inflammation Research Antibodies

Neurotransmission Research Antibodies                      

Schwann Cell or PNS Neuronal Markers 

Neurodegenerative Disease Research Antibodies    

Cancer Research Antibodies

Cancer Research Proteins                            

Neurotrophins-Neuron/Glial Marker Proteins

Stem Cell Research Reagents

Primary Neurons and Astrocytes-Primary human, rat and mouse neurons and astrocytes by Category

 

  

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Image: PGP9.5 staining of epithelial cells in porcine distal colon. Nerve fibers immunoreactive for the neural marker PGP 9.5 (red) are in close proximity to both IgA-immunoreactive plasma cells (green) and epithelial cells immunoreactive for SC (blue) in the colonic crypts. Abbreviations: Cr, colonic crypt; L, intestinal lumen; SM, submucosa. Scale bars: A, 100 μm. J Neuroimmunol. Published online 2007 February 21. doi: 10.1016