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Toll like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities have been implicated in the innate host defense to pathogens.

Image: Toll-Like Receptor 4 (TLR4 or CD284) staining of immersion fixed paraffin-embedded sections of human prostate at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent.  Tissue was stained using the Anti-Goat HRP-DAB. (brown) and counterstained with hematoxylin (blue)

These microbial molecular markers may be composed of proteins, carbohydrates, lipids, nucleic acids and/or combinations thereof. Individual TLRs recognize distinct pathogen-associated PAMPs, initiating signaling cascades that promote the immune response. Structurally, TLRs are type I transmembrane receptors that possess varying numbers of extracellular N-terminal leucine-rich repeat (LRR) motifs, followed by a cysteine-rich region, a TM domain, and an intracellular Toll/IL-1 R (TIR) motif.

NameCatalog #TypeSpeciesApplicationsSizePrice
TLR2/CD282RA30054Rabbit IgGHIHC; WB50 ug$365
TLR2/CD282GT15234Goat IgGHWB; FC100 ug$365
TLR3/CD283MO15121Mouse IgGMWB; E100 ug$255
TLR4/CD284GT15235Goat IgGHIHC; WB; FC; NB100 ug$365
TLR6/CD286RA30053Rabbit IgGHIHC; WB50 ug$365
TLR9/CD289RA25070Rabbit IgGH; Pr; RWB100 ul$325