Toll-Like Receptors or TLRs
Toll like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities have been implicated in the innate host defense to pathogens.
Image: Toll-Like Receptor 4 (TLR4 or CD284) staining of immersion fixed paraffin-embedded sections of human prostate at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent. Tissue was stained using the Anti-Goat HRP-DAB. (brown) and counterstained with hematoxylin (blue)
These microbial molecular markers may be composed of proteins, carbohydrates, lipids, nucleic acids and/or combinations thereof. Individual TLRs recognize distinct pathogen-associated PAMPs, initiating signaling cascades that promote the immune response. Structurally, TLRs are type I transmembrane receptors that possess varying numbers of extracellular N-terminal leucine-rich repeat (LRR) motifs, followed by a cysteine-rich region, a TM domain, and an intracellular Toll/IL-1 R (TIR) motif.
|TLR2/CD282||RA30054||Rabbit IgG||H||IHC; WB||50 ug||$365|
|TLR2/CD282||GT15234||Goat IgG||H||WB; FC||100 ug||$365|
|TLR3/CD283||MO15121||Mouse IgG||M||WB; E||100 ug||$255|
|TLR4/CD284||GT15235||Goat IgG||H||IHC; WB; FC; NB||100 ug||$365|
|TLR6/CD286||RA30053||Rabbit IgG||H||IHC; WB||50 ug||$365|
|TLR9/CD289||RA25070||Rabbit IgG||H; Pr; R||WB||100 ul||$325|