FOX

FOX or Forkhead box Proteins are a family of transcriptional regulators that are defined by a conserved 100-amino acid DNA-binding domain. They regulate diverse cellular processes including differentiation, metabolism, development, proliferation, and apoptosis.

Many are involved in embyrogensis and organogenesis. This includes the regulation of stem cells and progenitors.

Image: FOXE1 (dilution:  2.5µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on Data-sheet.

The misregulation and/or mutation of FOX genes often induce human genetic diseases, promote cancer or deregulate ageing. Indeed, germinal FOX gene mutations cause diseases ranging from infertility to language and/or speech disorders and immunological defects.