Presenilins are a family of related multi-pass transmembrane proteins that function as a part of the gamma-secretase protease complex. Presenilins undergo cleavage in an alpha helical region of one of the cytoplasmic loops to produce a larger N-terminal and a smaller C-terminal fragment which together form part of the functional protein. Cleavage of presenilin 1 can be prevented by a mutation which causes the loss of exon 9, and results in loss of function. Presenilins play a key role in the modulation of intracellular Ca2+ involved in presynaptic neurotransmitter release and long-term potentiation induction.
Dominant mutations in the genes that encode presenilin proteins are the most common cause of familial early-onset Alzheimer's disease.
|Presenilin 1||GT15027||Goat IgG||H||IHC; WB; E||100 ug||$365|
|Presenilin 1||RA18020||Rabbit IgG||H; M; Pr; R||WB; IP||200 ul||$330|
|Presenilin 2||RA18004||Rabbit IgG||H; M; Pr; R||ICC; IHC; WB; IP||100 ul||$310|