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Type: Protein
 
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Description/Data:
Picture

Acidic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis.
Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.

Image: FGF1, Sf9 insect derived protein structure and sequence

References:
1. Acidic FGF enhances functional regeneration of adult dorsal roots. Life Sci 2004 Feb 27;74(15):1937-43
2. Locally reduced levels of acidic FGF lead to decreased expression of 28-kda calbindin and contribute to the selective vulnerability of the neurons in the entorhinal cortex in Alzheimer's disease. Neuropathology 2001 Sep;21(3):203-11
3. Influence of IN-1 antibody and acidic FGF-fibrin glue on the response of injured corticospinal tract axons to human Schwann cell grafts. J Neurosci Res 1997 Dec 1;50(5):888-905
4. Acidic FGF regulation of hyperproliferation of fibroblasts in human autosomal dominant polycystic kidney disease.  Biochem Mol Med 1997 Aug;61(2):178-91
5. Effect of basic (FGF-2) and acidic (FGF-1) fibroblast growth factors on early haemopoietic cell development.  Br J Haematol 1996 Jun;93(4):772-82
6. Acidic FGF induces NGF and its mRNA in the injured neocortex of adult animals.  Brain Res Mol Brain Res 1995 Oct;33(1):1-6