PDGF - AA Human

PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGF is stored in platelet alpha-granules and released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB.

Image: PDGF-AA Structure and Sequence.

References:

1. Expression of survivin, platelet-derived growth factor A (PDGF-A) and PDGF receptor alpha in primary central nervous system lymphoma.  J Neurooncol 2006 Sep;79(2):171-9.
2. Nucleotide structure of equine platelet-derived growth factor-A and -B and expression in horses with induced acute tendinitis.  Am J Vet Res 2006 Jul;67(7):1218-25.
3. Effect of ischemic preconditioning on pancreatic regeneration and pancreatic expression of vascular endothelial growth factor and platelet-derived growth factor-A in ischemia/reperfusion-induced pancreatitis.  J Physiol Pharmacol 2006 Mar;57(1):39-58.
4. Expression of two alternative transcription forms of platelet-derived growth factor-A chain in the normal human kidney and in glomerulonephritis.  Rocz Akad Med Bialymst 2004;49:201-8.
5. [The role of platelet-derived growth factor A (PDGF-A) in hypertension and renal diseases. Part 2: a role of PDGF-A in kidney diseases]  Pol Merkur Lekarski 2004 Apr;16(94):403-5.
6. [The role of platelet-derived growth factor A (PDGF-A) in hypertension and renal diseases. Part 1: Structure and regulation of the PDGF-A gene expression and its role in hypertension]  Pol Merkur Lekarski 2004 Apr;16(94):398-401.