|
| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| PR27043-5 | 5 ug | $75.00 | Buy Now | Add to Cart |
| PR27043-20 | 20 ug | $175.00 | Buy Now | Add to Cart |
Proliferating cell nuclear antigen (PCNA), a protein of 30 kDa molecular weight also known as cyclin, forms a trimer ring around a DNA double-helix. It binds to a variety of other nuclear proteins and thereby organises biochemical processes at the DNA replication fork. PCNA thereby assumes important functions in DNA synthesis, repair and processing, the regulation of cell cycle and even apoptosis.
Anti-PCNA antibodies occur in systemic lupus, where they represent a rare specificity (< 10 % of SLE patients). However, their presence alone or in combination with other autoantibodies should alert the clinician to the presence of defined or evolving SLE.
Applications:
2. Standard ELISA test (checker-board analysis of positive/negative sera panels, immuno-dot analysis with validated SLE patient sera)
References:
1. Expression of glucose transporter-1, hexokinase-II, proliferating cell nuclear antigen and survival of patients with pancreatic cancer. Cancer Invest 2007 Apr-May;25(3):154-62.
2. Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer. Cancer Res 2007 Mar 15;67(6):2568-76.
3. Tumour suppressor protein (p53), apoptosis inhibiting protein (Bcl-2) and proliferating cell nuclear antigen (PCNA) expressions in a rat pancreatic tumour model. Anticancer Res 2007 Jan-Feb;27(1A):23-6.
4. Benzo[a]pyrene up-regulates the expression of the proliferating cell nuclear antigen (PCNA) and multixenobiotic resistance polyglycoprotein (P-gp) in Baltic Sea blue mussels (Mytilus edulis L.). Comp Biochem Physiol C Toxicol Pharmacol 2007 Mar;145(2):265-74.
5. [Effects of butyrylchitosan on expression of proliferating cell nuclear antigen in fibroblast proliferation of rabbit eyes after filtering operation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006 Dec;28(6):813-6.
6. Expression patterns of proliferating cell nuclear antigen in trichloroacetic acid peeled skin. J Dermatol 2007 Feb;34(2):95-8.