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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| PR27044-2 | 2 ug | $225.00 | Buy Now | Add to Cart |
| PR27044-5 | 5 ug | $350.00 | Buy Now | Add to Cart |
p21/WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21/WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21/WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. Meanwhile, the p21/WAF1 protein also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process. Evidently, inactivation of p53 disrupts the p53-dependent expression of p21/WAF1. p21/WAF1is a tumor suppressor involved in the pathogenesis of a variety of malignancies.
Image: P21/WAF1 structure and sequence.
References:
1. P21/WAF1 is an independent survival prognostic factor for patients with hepatocellular carcinoma after resection. Liver Int 2007 Aug;27(6):772-81.
2. Immunoreactivity of p53, Mdm2, p21(WAF1/CIP1) Bcl-2, and Bax in soft tissue sarcomas: correlation with histologic grade. Appl Immunohistochem Mol Morphol 2007 Mar;15(1):64-9.
3. Sp1 and Smad3 are required for high glucose-induced p21(WAF1) gene transcription in LLC-PK(1) cells. J Cell Biochem 2007 May 21.
4. p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. Oncogene 2007 May 7.
5. Expression of p21(WAF1) is related to acetylation of histone H3 in total chromatin in human colorectal cancer. World J Gastroenterol 2007 Apr 21;13(15):2209-13.
6. Expression of the HER family mRNA in breast cancer tissue and association with cell cycle inhibitors p21(waf1) and p27(kip1). Anticancer Res 2007 Mar-Apr;27(2):913-20.