Picture

The growth cone at the tip of an extending axon is exquisitely sensitive to repulsive and attractive guidance cues in its environment. These molecules may be diffusible and work from a distance, or may be bound to a membrane or substrate and work at close range. It is the complex integration of these repulsive and attractive signals that enhance or suppress axon outgrowth, and/or guide the axon to its appropriate target. These molecules play critical roles during nervous system development and may regulate the regeneration during nervous system disease.

Images: Growth Cone Collapse by Semaphorin 6B/Fc. A) A fully extended dorsal root ganglion (DRG) growth cone growing on a laminin-coated tissue culture plate in te presence of beta-NGF. B) A collapsed DRG growth cone following treatment from Semaphorin 6B/Fc.

NameCatalog #TypeSpeciesApplicationsSizePrice
Activin APR15010ProteinH; M; R10 ug
50 ug
$250
$760
Activin A, CFPR15010CFProteinH; M; R10 ug
50 ug
$250
$760
Activin ABPR15011ProteinH5 ug$330
Activin AB, CFPR15011CFProteinH5 ug$330
Activin BPR15012ProteinH5 ug
25 ug
$250
$760
BMP-2PR27023-2ProteinH2 ug
10 ug
$108
$205
BMP-2 (E. coli-expressed), CFPR15014CFProteinH10 ug$200
BMP-2 (E.coli-expressed)PR15014ProteinH10 ug$200
BMP-2, CFPR15013CFProteinH10 ug$450
BMP-4PR27024-2ProteinH2 ug
10 ug
$108
$205
BMP-4PR15015ProteinH10 ug$435
BMP-4, CFPR15015CFProteinH10 ug$435
BMP-7PR27026-2ProteinH2 ug
10 ug
$108
$205
BMP-7 CHOPR27001-2ProteinH2 ug
10 ug
$108
$205
Contactin-1, FC ChimeraPR15072-100ProteinH; R100 ug$325
Contactin-4PR15073-25ProteinH; R25 ug$315
EphA4/Fc Chimera, CFPR15069CF-200ProteinM200 ug$265
Ephrin B1PR27094-5ProteinH5 ug
20 ug
$108
$205
Ephrin B3PR27095-2ProteinH2 ug
5 ug
$185
$290
Galectin-1 (LGAS1)PR27143-10ProteinH10 ug
50 ug
1 mg
$108
$205
$1,450
GDF-5PR27028-10ProteinH10 ug
50 ug
$108
$205
GDNF (Human, Mouse)PR27022-2ProteinH; M2 ug
10 ug
$108
$205
GDNF (Rat)PR15008ProteinR10 ug
50 ug
$285
$940
GDNF (Rat), Carrier FreePR15008CFProteinR10 ug
50 ug
$285
$940
MAG/Siglec4a Fc Chimera, CFPR15078-100ProteinR100 ug$325
MANF/ARMET, CFPR15079CFProteinH; M; R50 ug$325
NGF-b, Human, CHOPR27002-5ProteinH5 ug
20 ug
$108
$205
NGF-b, MousePR27003-5ProteinM5 ug
20 ug
$108
$205
NGF-b, NSO DerivedPR15083ProteinH; M; R100 ug$285
NGF-b, NSO Derived, CFPR15084CFProteinH; M; R100 ug$285
NOGO APR15067ProteinR50 ug$320
NeurofascinPR15066ProteinR50 ug$320
OMgpPR15054-25ProteinH25 ug$315
RetPR15043-50ProteinH50 ug$315
Ret, CFPR15043CF-10ProteinH10 ug$315
Ret/FC ChimeraPR15049-100ProteinM100 ug$340
Ret/FC Chimera, Carrier FreePR15049CF-100ProteinM100 ug$340
S100A13, Carrier FreePR15076CF-50ProteinH; R50 ug$315
Semaphorin 6B/FcPR15065ProteinH50 ug$320
Slit1PR15075-50ProteinCh; H50 ug$315
Slit2, CHOPR15085-50ProteinCh; H50 ug$315
Sonic HedgehogPR15000ProteinM25 ug
25 ug
$255
$255
Sonic Hedgehog (C24II) N-TerminusPR15018ProteinH25 ug$315
Sonic Hedgehog (C24II) N-Terminus, CFPR15018CFProteinH25 ug$315
Sonic Hedgehog N-Terminus (Shh-N)PR15019ProteinH25 ug$285
Sonic Hedgehog N-Terminus (Shh-N), CFPR15019CFProteinH25 ug$285
Stem Cell Factor/KIT LigandPR27121-2ProteinR2 ug
20 ug
$108
$205
Stem Cell Factor/KIT LigandPR27122-2ProteinH2 ug
10 ug
$108
$205
TGF Beta1PR15009ProteinH1 ug$250
TGF-alpha, CFPR15016CFProteinH100 ug
500 ug
$315
$990