CD40 Ligand/TRAP (Soluble)

CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines . CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2 .

Image: CD40 Ligand/TRAP Structure and Sequence

References:

1. CD154-stimulated GM-CSF release by vascular smooth muscle cells elicits monocyte activation-role in atherogenesis. J Mol Med 2007 Jul 10;
2. Serum CD40/CD40L system in Graves' disease and Hashimoto's thyroiditis related to soluble Fas, FasL and humoral markers of autoimmune response. Immunol Invest 2007;36(3):247-57
3. [Correlation between CD154 (CD40L) expression and naive/memory CD4(+) T cells.] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007 Jun;23(6):491-4
4. Homocysteine modulates the CD40/CD40L system. J Am Coll Cardiol 2007 Jun 5;49(22):2182-90
5. CD40-CD40L Interaction in Immunity Against Protozoan Infections. J Biomed Biotechnol 2007;2007(3):59430
6. Cutting edge: small molecule CD40 ligand mimetics promote control of parasitemia and enhance T cells producing IFN-gamma during experimental Trypanosoma cruzi infection. J Immunol 2007 Jun 1;178(11):6700-4