CD105 (Endoglin)

CD105 (26-176 a.a.) or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. CD105 binds to TGFBeta1 and Beta3 with high affinity but not TGF-Beta2.

Image: CD105 structure and sequence.

References:

1. Targeting a marker of the tumour neovasculature using a novel anti-human CD105-immunotoxin containing the non-toxic type 2 ribosome-inactivating protein nigrin b. Cancer Lett 2007 Jul 14;
2. Particular distribution and expression pattern of endoglin (CD105) in the liver of patients with hepatocellular carcinoma. BMC Cancer 2007 Jul 4;7(1):122
3. Density of microvessels positive for CD105 (endoglin) is related to prognosis in meningiomas. Acta Neuropathol (Berl) 2007 Aug;114(2):147-56
4. CD105/smooth muscle actin double immunostaining discriminate between immature and mature tumor blood vessels. Rom J Morphol Embryol 2007;48(1):41-5
5. Relationship between intravascular ultrasound imaging features of coronary plaques and soluble CD105 level in patients with coronary heart disease. Chin Med J (Engl) 2007 Apr 5;120(7):595-7
6. [Expressions of hTERT, HIF-1alpha and CD105 in gliomas and their clinical significance] Zhonghua Bing Li Xue Za Zhi 2006 Nov;35(11):681-2