ICAM-1/CD54

ICAM-1 (CD54) is a single chain membrane glycoprotein expressed on the surface of a variety of non-haematopoietic and haematopoietic cell types and has roles in signal transduction, cell signalling and lymphocyte adhesion. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory conditions. Intercellular adhesion molecule 1 (ICAM-1) is the cellular receptor for the major group of human rhinovirus serotypes, including human rhinovirus 14 (HRV14) and HRV16.

Image: ICAM-1 structure and sequence.

References:

1. A model of the complex between the PfEMP1 malaria protein and the human ICAM-1 receptor. Proteins 2007 Jul 19;
2. Arachidonic Acid but not Eicosapentaenoic Acid (EPA) and Oleic Acid Activates NF-kappaB and Elevates ICAM-1 Expression in Caco-2 Cells. Lipids 2007 Aug;42(8):687-98
3. HTLV-1 p12I down-modulates ICAM-1 and -2 and reduces natural killer cell adherence thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on the infected cells. J Virol 2007 Jul 3;
4. [The influence of erythropoietin (Epo) on intercellular adhesion molecule-1 (ICAM-1, CD54) and platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) expression on human umbilical vein endothelial cells (HUVEC) induced by tumor necrosis factor-alpha (TNF-alpha)] Wiad Lek 2007;60(1-2):22-7
5. Hyaluronan inhibits cytokine production by lipopolysaccharide-stimulated U937 macrophages through down-regulation of NF-kappaB via ICAM-1. Inflamm Res 2007 Jun;56(6):246-53
6. Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes. Mol Immunol 2007 Jun 29