SHANK 1a C-terminusIHC and Protocols from Multiple Labs |
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We have received positive feedback on the Shank 1a C-terminus staining in mouse retinal tissue.
Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.
Shank1 A has also been found to be associated with L-type Ca2+ channels. Olson et al., J Neurosci. 2005, 25:1050-62; Zhang et al., J Neurosci. 2005, 25:1037-49) the same channels used by photoreceptors for transmitter release.
IHC Staining in Mouse Retina
Image and protocol courtesy of Sal Stella, UCLA
Image courtesy of Alex Vila, UCLA