Insulysin/IDE

Mouse Monoclonal Antibody

DATASHEET (pdf - 60Kb)

Open Shopping Cart

Catalog Number	Size	Price (USD)	Shopping Cart
MO15081	100 ug	$235.00	Buy Now \| Add to Cart

Type: Mouse IgG

Applications: WB; FC

ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; All Fluorecent Images;

Species Reactivity: H; M; Pr; R

B=Bovine; Ca=Cat; Ch=Chicken; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Ze=Zebrafish; na

Format: Protein G Purified - liquid

Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf21-derived, recombinant human insulysin/insulin degrading enzyme (rhIDE; Accession # NP_004960, aa 42 – 1019). Clone#: 334501.

Description/Data:

Insulysin, a wide expressed protein, is responsible for the degradation of insulin in cells. Primarily located in the cytosol, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B-chain, glucagon, denatured hemoglobin, alpha-amyloid protein, TGF-alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer's disease research.

Figure: HeLa cells were stained with anti-Insulysin (filled histogram) or isotype control (open histogram) followed by APC-conjugated rat antibody

Other Reagents to Consider:

Insulysin/IDE-Goat

Insulin

Matrix Metalloproteinases (MMPs)

Beta-Amyloid (1-40)

Beta-Amyloid (1-42)

All Diabetes and Obesity Antibodies

All Neurodegenerative Disease Antibodies

All Diabetes and Obesity Proteins

Insulysin/IDE-Goat

Diabetes and Obesity Research Antibodies