Product Details
Catalog Number: 4391-50
Type: Inhibitor
Format B: lyophilized
Species Reactivity: All
Product Sizes
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50 mg$979.00Add to Cart

Biological Activity

Potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable.

Images
2-[[4-Amino-5-[5-iodo-4-methoxy-2-(­1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-­propanediol

2-[[4-Amino-5-[5-iodo-4-methoxy-2-(­1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-­propanediol

2-[[4-Amino-5-[5-iodo-4-methoxy-2-(­1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-­propanediol

2-[[4-Amino-5-[5-iodo-4-methoxy-2-(­1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-­propanediol