Collagen is a fibrous protein found in the extracellular matrix and connective tissue. The most common form of collagen is type I and is most prevalent in bone, tendon and skin. It consists of 3 intertwined coiled subunits: 2 x α1 (I) chains and 1 x α2 (I) chain. Each chain contains 1050 amino acids wound tightly around one another in a characteristic right-handed triple helix. The triple-helical structure of collagen arises from unique abundance of the amino acids in collagen appear in a characteristic repeating motif Gly-X-Y, where X is usually proline and Y is usually hydroxyproline.
AlphaBioCoat Solution (AC001) is a biocompatible complex of extracellular matrix binding solution that is supplemented with growth factors. It helps accelerate cell attachment and cell growth.
AC001 is the premium version of our Smooth Coat Solution (SC300). It is ideal for plate coating due to its unique viscosity. Its coating greatly enables cell migration on cultured plate surfaces. Perfect for establishing primary cell lines, it can increase endothelial cell attachment, survival in culture, and cell growth. AlphaBioCoat Solution is great for both coating plates and T-flasks. Highly recommended to use when culturing cells from frozen.
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- Fumiaki Shima and Tomomi Makino. (2022). Construction of Brain-Like Spheroids Containing Endothelial Tubular Networks by an Adhesive Culture System. Biochemical and Biophysical Research Communications. doi: 10.1016/j.bbrc.2022.07.063
- Sabine Heitzeneder, Kristopher R. Bosse, Zhongyu Zhu, Doncho Zhelev, Robbie G. Majzner, Molly T. Radosevich, Shaurya Dhingra, Elena Sotillo, Samantha Buongervino, Guillem Pascual-Pasto, Emily Garrigan, Peng Xu, Jing Huang, Benjamin Salzer, Alberto Delaidelli, Swetha Raman, Hong Cui, Benjamin Martinez, and Crystal L. Mackall. (2021). GPC2-CAR T Cells Tuned for Low Antigen Density Mediate Potent Activity Against Neuroblastoma Without Toxicity. Cancer Cell, 40, 1–17. doi: 10.1016/j.ccell.2021.12.005
- A. Gericke, K. Suminska-Jasinska, and A. Breborowicz. (2021). Sulodexide Reduces Glucose Induced Senescence in Human Retinal Endothelial Cells. Scientific Reports, 11:11532. doi: 10.1038/s41598-021-90987-w
- Ece Bayir, M. Mert Celtikoglu, Aylin Sendemir. (2018). The use of bacterial cellulose as a basement membrane improves the plausibility of the static in vitro blood-brain barrier model. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2018.12.257
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