Product Details
Catalog Number: CH23003
Applications: ICC, WB, IHC
Type: Chicken IgY
Dilutions: ICC 1:100-1:200; IHC 1:100-1:200; WB 1:250-1:500
Immunogen: Peptide common to the rat (AAA41119) and human (NP_001966) NSE
Storage: Store at 4°C in the dark
Shipping: Ambient
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 2026
UniProt: P09104
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Human Neuron specific enolase (NSE) (EC 4.2.1.11) is a 47,138 dalton protein (434 amino acids) expressed in neurons of the peripheral nervous system (PNS) and central nervous system (CNS). NSE catalyzes the conversion of 2-phospho-Dglycerate into phosphoenol pyruvate, and is an essential enzyme in energy metabolism in nervous tissues.

NSE corresponds to ENO2 or enolase gamma and is heavily expressed in neuronal cells, developing neuronal lineage and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood has also been used as a biomarker of neuronal injury.

Images
Dissociated cell cultures of neonatal mouse brains, showing NSE (green staining) in neurons.These cultures were counter-stained with a rabbit anti-GFAP to localize astrocytes, as well as with DAPI (blue staining) to localize nuclei.

Dissociated cell cultures of neonatal mouse brains, showing NSE (green staining) in neurons.These cultures were counter-stained with a rabbit anti-GFAP to localize astrocytes, as well as with DAPI (blue staining) to localize nuclei.

Dissociated cell cultures of neonatal mouse brains, showing NSE (green staining) in neurons.These cultures were counter-stained with a rabbit anti-GFAP to localize astrocytes, as well as with DAPI (blue staining) to localize nuclei.

Dissociated cell cultures of neonatal mouse brains, showing NSE (green staining) in neurons.These cultures were counter-stained with a rabbit anti-GFAP to localize astrocytes, as well as with DAPI (blue staining) to localize nuclei.