Product Details
Catalog Number: CH23004
Applications: ICC, WB, IHC
Type: Chicken IgY
Dilutions: ICC 1:100-1:200; IHC 1:100-1:200; WB 1:250-1:500
Immunogen: Peptide common to mouse (P06837) and human (NP_002036) GAP43
Storage: Store at 4°C in the dark
Shipping: Ambient
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 2596
UniProt: P17677
Downloads: Datasheet (pdf)
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Human GAP-32 is a 24,672 dalton protein (283 amino acids) expressed in neurons during development and reexpressed during axonal regeneration. It is also known as neuromodulin, calmodulin--binding protein P57, protein F1, and B-50. It is found in neuronal cell bodies, axons, and growth cones.Although its function has long been debated, it seems likely that GAP-43 may act as an osmosensory protein regulating intracellular calcium levels.

Images
Dissociated cell culture from an e13 mouse brain showing GAP-43 (green staining) of a neuron. Note the presence of GAP-43 within the cell body, as well as within the growth cones at the end of each neurite.

Dissociated cell culture from an e13 mouse brain showing GAP-43 (green staining) of a neuron. Note the presence of GAP-43 within the cell body, as well as within the growth cones at the end of each neurite.

Dissociated cell culture from an e13 mouse brain showing GAP-43 (green staining) of a neuron. Note the presence of GAP-43 within the cell body, as well as within the growth cones at the end of each neurite.

Dissociated cell culture from an e13 mouse brain showing GAP-43 (green staining) of a neuron. Note the presence of GAP-43 within the cell body, as well as within the growth cones at the end of each neurite.