Human Myelin Protein Zero (Po) is a 28400 dalton protein (258 amino acids) found in myelin of the PNS. Expressed in myelinating Schwann cells, Po serves as a homophilic adhesion molecule, allowing adjacent laminae of the myelin sheath to undergo compaction. Po is also a marker of a subpopulation of neural crest cells. Mutations of the MPZ gene product in humans is responsible for Charcot-Marie-Tooth type 1B neuropathies (HMSN1B).
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- David F Russell, Desmon E Rogers, Lilia L Neiman (2019). Nonbinary branching of myelinated dendrites at nodal networks on afferent terminal arbors in paddlefish electroreceptors. Matters. DOI: 10.19185/matters.201812000003
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- Silvia Murillo-Cuesta, Guadalupe Camarero, Águeda González-Rodríguez, Lourdes Rodríguez-de la Rosa, Deborah J Burks, Carlos Avendaño, Ángela M Valverde and Isabel Varela-Nieto. (2011). Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function. Molecular Medicine, doi: 10.2119/molmed.2011.00328
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