Human Myelin Protein Zero (Po) is a 28400 dalton protein (258 amino acids) found in myelin of the PNS. Expressed in myelinating Schwann cells, Po serves as a homophilic adhesion molecule, allowing adjacent laminae of the myelin sheath to undergo compaction. Po is also a marker of a subpopulation of neural crest cells. Mutations of the MPZ gene product in humans is responsible for Charcot-Marie-Tooth type 1B neuropathies (HMSN1B).
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- Wiebke Kallenborn-Gerhardt, Katrin Schröder, Domenico Del Turco, Ruirui Lu, Katharina Kynast, Judith Kosowski, Ellen Niederberger, Ajay M. Shah, Ralf P. Brandes, Gerd Geisslinger, and Achim Schmidtko. (2012). NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury. The Journal of Neuroscience, 32(30): 10136-10145; doi: 10.1523/JNEUROSCI.6227-11.2012
- Silvia Murillo-Cuesta, Guadalupe Camarero, Águeda González-Rodríguez, Lourdes Rodríguez-de la Rosa, Deborah J Burks, Carlos Avendaño, Ángela M Valverde and Isabel Varela-Nieto. (2011). Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function. Molecular Medicine, doi: 10.2119/molmed.2011.00328
- Christopher P Irmen, Sandra M Siegel and Patrick A Carr. (2008). Localization of SSeCKS in unmyelinated primary sensory neurons. Journal of Brachial Plexus and Peripheral Nerve Injury 2008, 3:8, doi: 10.1186/1749-7221-3-8
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