Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. In the electron microscope neurofilaments appears as 10nm diameter fibres of indeterminate length which generally have fine wispy protrusions from their sides. They are found particularly abundantly in axons of large projection neurons. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons, and are biochemically very stable.
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- Yingpeng Liu, Lakshmi Kelamangalath, Hyukmin Kim, Seung Baek Han, Xiaoqing Tang, Jinbin Zhai, Jee W. Hong, Shen Lin, Young-Jin Son, George M. Smith. (2016). NT-3 promotes proprioceptive axon regeneration when combined with activation of the mTor intrinsic growth pathway but not with reduction of myelin extrinsic inhibitors. Experimental Neurology, doi: 10.1016/j.expneurol.2016.05.021
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