Product Details
Catalog Number: CH23022
Applications: ICC, IHC
Type: Chicken IgY
Immunogen: Synthetic peptide-keyhole limpet hemocyanin (KLH) conjugate. This synthetic peptide corresponded to the Fox-3 gene product (also known as the Neu-N antigen), but was shared between the human NP_001076044, NCBI) and mouse (NP_001020102, NCBI) sequences.
Storage: Store at 4°C in the dark
Shipping: Ambient
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 146713
UniProt: A6NFN3
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$125.00Add to Cart

Fox3 is one of a family of 3 mammalian Fox homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X". The Fox protein and its 3 mammalian homologues are all about 46kDa proteins each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70 amino acid structure consisting of 4 beta strands and two alpha-helices. An alternate name for Fox 3 is hexaribonucleotide binding protein 3, and these proteins are believed to have a role in the regulation of mRNA splicing.

Much interest has focused on Fox3 as this protein corresponds to NeuN, a neuronal nuclear antigen. NeuN antibody has become very widely used as a robust marker of neurons and neuronal stem cells. Fox3 is therefore a protein which has a funciton in RNA splicing and is expressed heavily and specifically in neuronal nuclei.

Images
FOX3 (red) and and beta-tubulin (Green) staining of cochlear ganglion of a neonatal mouse. Protocol on Data-sheet.

FOX3 (red) and and beta-tubulin (Green) staining of cochlear ganglion of a neonatal mouse. Protocol on Data-sheet.

FOX3 (red) and and beta-tubulin (Green) staining of cochlear ganglion of a neonatal mouse. Protocol on Data-sheet.

FOX3 (red) and and beta-tubulin (Green) staining of cochlear ganglion of a neonatal mouse. Protocol on Data-sheet.