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Size | List Price | Price | Cart |
---|---|---|---|
100 ul | $125.00 | Add to Cart |
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells mGluR1 modulates excitatory and inhibitory synaptic transmission in various brain areas including the activation of glutamate-driven synaptic inhibition in the cerebellum. mGluR1 and other mGluRs have emerged as therapeutic targets for neuropsychiatric disorders associated with cortical dysfunction and the modulation of nociceptive and neuropathic pain. |
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Adult mouse cochlear ganglion stained with mGluR1 (green) and Tuj-1 (CH23005, red). Protocol on datasheet.
Adult mouse cochlear ganglion stained with mGluR1 (green) and Tuj-1 (CH23005, red). Protocol on datasheet.