Product Details
Catalog Number: CH23023
Applications: IHC
Type: Chicken IgY
Dilutions: ICC 1:100-1:200; IHC 1:100-1:200; WB 1:250-1:500
Immunogen: Synthetic peptides corresponding to different regions of the metabotropic glutamate receptor type 1 gene product but are shared between the human (NP_000829.2, NCBI) and mouse (NP_058672.1, NCBI) sequences.
Storage: Store at 4°C in the dark
Shipping: Ambient
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 2911
UniProt: Q13255
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$125.00Add to Cart

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells

mGluR1 modulates excitatory and inhibitory synaptic transmission in various brain areas including the activation of glutamate-driven synaptic inhibition in the cerebellum. mGluR1 and other mGluRs have emerged as therapeutic targets for neuropsychiatric disorders associated with cortical dysfunction and the modulation of nociceptive and neuropathic pain.

Images
Adult mouse cochlear ganglion stained with mGluR1 (green) and Tuj-1 (red). Protocol on datasheet.

Adult mouse cochlear ganglion stained with mGluR1 (green) and Tuj-1 (CH23005, red). Protocol on datasheet.

Adult mouse cochlear ganglion stained with mGluR1 (green) and Tuj-1 (red). Protocol on datasheet.

Adult mouse cochlear ganglion stained with mGluR1 (green) and Tuj-1 (CH23005, red). Protocol on datasheet.