Product Details
Catalog Number: CH23033
Applications: ICC, IHC
Type: Chicken IgY
Immunogen: Peptide common to mouse (AAT58219.1) and human (CAA06617.1) Doublecortin
Storage: Store at 4°C in the dark
Shipping: Ambient
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 1641
UniProt: O43602
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$99.00Add to Cart

Doublecortin (also known as doublecortex, lissencephalin) a microtubule-associated phosphoprotein coded by the gene DCX. Doublecortin binds to microtubules during neuronal migration promoting stability. Doublecortin immunostaining can be used as a marker of new neurons in the adult dentate gyrus and could be used to analyze changes in dentate neurogenesis in hippocampal tissue to study ageing or neurodegenerative diseases.

Mutations to the gene DCX has been shown to lead to isolated lissencephaly sequence (ILS). Individuals with ILS have abnormal brain development that results in lissenecephaly (smooth appearance) instead of the brain’s normal gyri and sulci. Mutations to DCX can also lead to subcortical band heterotopia; which is the migration of neurons to incorrect locations in the brain.

Images
Cochlear neurons in the cochlear ganglion of an adult mouse brain stained green with doublecortin. Neurofilament immunoreactivity stained red using a rabbit antibody.

Cochlear neurons in the cochlear ganglion of an adult mouse brain stained green with doublecortin. Neurofilament immunoreactivity stained red using a rabbit antibody.

Cochlear neurons in the cochlear ganglion of an adult mouse brain stained green with doublecortin. Neurofilament immunoreactivity stained red using a rabbit antibody.

Cochlear neurons in the cochlear ganglion of an adult mouse brain stained green with doublecortin. Neurofilament immunoreactivity stained red using a rabbit antibody.