Product Details
Catalog Number: CH23108
Applications: ICC, WB, IHC
Type: Chicken IgY
Immunogen: Purified recombinant extracellular domain of human TREM2 expressed in E.Coli
Storage: Store at 4°C in the dark.
Shipping: Ambient
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 54209
UniProt: Q9NZC2
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 µg$505.00Add to Cart
20 µg$149.00Add to Cart

Triggering receptor expressed on myeloid cells 2, TREM2, is a type I transmembrane innate immune receptor predominantly expressed by microglia in the central nervous system and is genetically linked to the risk for Alzheimer’s disease. TREM2 has been shown to be a specific marker for alternatively activated microglia known as M2 cells. TREM2 binds to its adaptor, DNAX-activating protein (DAP12) on the surface of microglia to enact innate immune responses and downstream cellular responses or signaling pathways. TREM2 has important roles in microglial phagocytosis of apoptotic neurons, damaged myelin, and amyloid plaques.

Images
Immunofluorescence

Immunofluorescence analysis of TREM2-FLAG transfected COS-7 cells using chicken α-TREM2 (green) and mouse α-flag tag (red). Yellow/orange staining shows 100% correspondence between the two antibodies for recognition of transfected cells. Blue staining is DAPI and stains nuclei of both transfected and untransfected cells.

Immunofluorescence

Immunofluorescence analysis of TREM2-FLAG transfected COS-7 cells using chicken α-TREM2 (green) and mouse α-flag tag (red). Yellow/orange staining shows 100% correspondence between the two antibodies for recognition of transfected cells. Blue staining is DAPI and stains nuclei of both transfected and untransfected cells.

Western Blot

Western blot of rat brain membrane lysate using chicken α-TREM2 showing specific immunolabeling of the endogenous TREM2 at ~35kDa.

Western Blot

Western blot of rat brain membrane lysate using chicken α-TREM2 showing specific immunolabeling of the endogenous TREM2 at ~35kDa.