Product Details
Catalog Number: CP51101
Storage: Keep frozen at -20°C.
Shipping: Frozen (Dry Ice/Liquid Nitrogen)
Format B: lyophilized
Downloads: Datasheet (pdf)
Product Sizes
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500 ugs$759.00Add to Cart

Penetratin™ 1 peptide is a patented 16-amino acid peptide corresponding to the third helix of the homeodomain of Antennapedia protein. It is able to translocate across biological membranes by an energy-independent mechanism and is a member of a class of peptides known as Cell Penetrating Peptides.

Penetratin™ 1 has been used successfully to internalize covalently attached peptides and oligonucleotides and to convey them to the cytoplasm and nucleus of many cell types. Activated Penetratin™ 1 peptide couples to oligos and peptides that carry a thiol (-SH) function.

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     References (review and mechanism approach)

    1. Troy, CM. et al., 2004, J. Neurosci. 24, 10040-10046 
    2. Damante, G. et al., 1996, EMBO J. 15, 4992-5000
    3. Derosssi, D. et al., 1996, J. Biol. Chem. 271, 18188-18193 
    4. Dorn, A. et al., 1994, Pharmac. Ther. 61, 155-183 
    5. Prochiantz A., 1996, Curr. Opin. Neurobiol. 6, 629-634
    6. Derossi, D. et al., 1998, Trends Cell Biol. 8, 84-87

    Further references

    1. Perez, F. et al., 1994, Mol. endocrinol. 8, 1278-1287
    2. Allinquant, B. et al., 1995, J. Cell. Biol. 128, 919-927 
    3. Derosssi, D. et al., 1995, J. Neurosci. 15, 7158-7167
    4. Le Roux, I. et al., 1995, FEBS Letters 368, 311-314 
    5. Fahraeus et al., 1996, Curr. Biol. 6, 84-91
    6. Hall, H. et al., 1996, Curr.Biol 6, 580-587 
    7. Schutze-Redelmeier, M. P. et al., 1996, J.of immunology 157, 650-655
    8. Troy, C. et al., 1996, Proc. Nat. Acad. Sci. 93, 5635-5640 
    9. Troy, C. et al., 1996, J. Neurosci. 16, 253-261 
    10. Bonfanti, M. et al., 1997, Cancer Res. 57, 1442-1446
    11. Williams, E.J. et al., 1997, J. Biol. Chem. 272, 22349-22354
    12. Boissy, P. et al., 1998, J. Cell Sci. 111, 2563-2574
    13. Joliot et al., 1998, Curr. Biol. 8, 856-863
    14. Peck, D. and Isacke, C.M., 1998, J. Cell Sci. 111, 1595-1601
    15. Bardelli, A.1999, J. Biol. Chem. 274, 29274-29288
    16. Fahraeus, R. and Lane, D.P.1999, EMBO J. 18, 2106-2118
    17. Wang, J. et al., 1999, Mol. cell Biol. 19, 6217-6228

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