Neurotrophin-3 (NT-3) and Neurotrophin-4 (NT-4) are members of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central and peripheral nervous systems. The neurotrophin family is comprised of at least four proteins, including NGF, BDNF, NT-3, and NT-4/5. The amino acid sequence of mature NT-3 is identical in human, mouse and rat. Mature human and rat NT-4 share approximately 95% amino acid sequence identity.
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- N. Weishaupt, A.L.O. Mason, C. Hurd,Z. May, D.C. Zmyslowski, D. Galleguillos, S. Sipione, K. Fouad. (2014). Vector-induced NT-3 expression in rats promotes collateral growth of injured corticospinal tract axons far rostral to a spinal cord injury. Neuroscience, doi: 10.1016/j.neuroscience.2014.04.041
- Laura Taylor Alto, Leif A Havton, James M Conner, Edmund R Hollis II, Armin Blesch & Mark H Tuszynski. (2009). Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nature Neuroscience, doi: 10.1038/nn.2365
- Leanne M. Ramer, Lowell T. McPhail, Jaimie F. Borisoff, Lesley J. J. Soril, Timothy K. Y. Kaan, Jae H. T. Lee, James W. T. Saunders, Lucy P. R. Hwi, and Matt S. Ramer. (2007). Endogenous TrkB Ligands Suppress Functional Mechanosensory Plasticity in the Deafferented Spinal Cord. The Journal of Neuroscience, 27(21):5812-5822. doi: 10.1523/JNEUROSCI.0491-07.2007
- Donald Ganchrow, Judith R. Ganchrow, Mary Verdin-Alcazar, Mark C. Whitehead. (2002). Brain-derived neurotrophic factor-, neurotrophin-3-, and tyrosine kinase receptor-like immunoreactivity in lingual taste bud fields of mature hamster. J. Comp. Neurol., 455(1): 11-24. doi: 10.1002/cne.2162
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