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GDNF, Neurturin, Artemin, and Persephin are distant members of the TGF-beta superfamily that function as neurotrophic factors. Their bioactivities are mediated by a receptor complex composed of the non-ligand-binding signaling subunit (c-Ret receptor tyrosine kinase) and one of four ligand binding subunits designated GFR alpha-1 through 4, which are cysteine-rich glycosyl-phosphatidylinositol (GPI)-linked cell surface proteins.
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- Erika K. Lippoldt, Russell R. Elmes, Daniel D. McCoy, Wendy M. Knowlton, and David D. McKemy. (2013). Artemin, a Glial Cell Line-Derived Neurotrophic Factor Family Member, Induces TRPM8-Dependent Cold Pain The Journal of Neuroscience, 24 July 2013, 33(30):12543-12552; doi: 10.1523/JNEUROSCI.5765-12.2013
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