Matrix Metalloproteases (MMPs) play important roles in many physiological or pathological processes including embryonic development, morphogenesis, reproduction, tissue remodeling, arthritis, cancer and cardiovascular disease. Membrane-Type MMPs (MT-MMPs) have emerged as an important subgroup. MMPs function in the breakdown of extracellular matrix and in the processing of a variety of biological molecules. MMP activities are regulated at multiple levels such as the activation of proenzymes and via suppression by tissue inhibitors of metalloproteinases (TIMPs).
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- Simon Schäfer, Stephanie Weibel, Ulrike Donat, Qian Zhang, Richard J Aguilar, Nanhai G Chen and Aladar A Szalay. (2012). Vaccinia virus-mediated intra-tumoral expression of matrix metalloproteinase 9 enhances oncolysis of PC-3 xenograft tumors. BMC Cancer 2012, 12:366 doi: 10.1186/1471-2407-12-366
- Yasuki Yasuda, Yoko Matsumura, Kazuki Kasahara, Noriko Ouji, Shigeki Sugiura, Keiichi Mikasa, and Eiji Kita. (2009). Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance. Am J Physiol Lung Cell Mol Physiol, doi: 10.1152/ajplung.00193.2009
- Zhi-Yuan Zhang, Zhiren Zhang, Uwe Fauser and Hermann J. Schluesener. (2008). Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline. Journal of Cellular and Molecular Medicine, doi: 10.1111/j.1582-4934.2008.00333
- Stephanie Weibel, Jochen Stritzker, Matthias Eck, Werner Goebel, and Aladar A. Szalay. (2008) Colonization of experimental murine breast tumours by Escherichia coli K-12 significantly alters the tumour microenvironment. Cellular Microbiology, doi: 10.1111/j.1462-5822.2008.01122.x
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