Cancer: Dendritic cells (DC) genetically modified ex vivo to overexpress CX3CR1/fractalkine would enhance the T cell-mediated cellular immune response with a consequent induction of anti-tumor immunity to suppress tumor growth. Recently,CX3CR1 /fractalkine was found to serve as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine.
Fractalkine has also been found to play a role in nociceptive pain might act tonically as an anti-inflammatory chemokine in cerebral tissue through its ability to control and suppress certain aspects of microglial activation. These data may have relevance to degenerative conditions such as multiple sclerosis, in which cerebral inflammatory processes may be activated.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size CSF1 (Colony Stimulating Factor 1) RA21013 50 ug CSF1 (Colony Stimulating Factor 1) RA21014 50 ug CXCL8/IL-8 GT15156 100 ug IL-1 alpha/IL-F1 GT15101 100 ug IL-1 beta (Mouse) GT15102 100 ug IL-1 beta (Rat) GT15105 100 ug IL-17 MO15110 100 ug IL-17 MO15110 500 ug IL-17E/IL-25 MO15111 100 ug IL-17E/IL-25 MO15111 500 ug IL-2 MO15069 100 ug IL-2 MO15069 500 ug IL-2 (Rat) GT15155 100 ug IL-4 MO15071 100 ug IL-4 MO15071 500 ug IL-6 (Mouse) GT15103 100 ug IL-6 (Rat) GT15106 100 ug Macrophage Inflammatory Protein 1alpha (MIP-1a)/CCL3 GT15070 100 ug Macrophage Inflammatory Protein 1alpha (MIP-1a)/CCL3 GT15070 50 ug Macrophage Inflammatory Protein 1beta (MIP-1beta)/CCL4 GT15071 100 ug TNF alpha GT15113 100 ug